A comprehensive genomic analysis of single cells is needed for numerous scenarios in tumor genetics, clinical diagnostics and forensic application. PCR protocols were developed which allow an unbiased ...

For some tumor entities, however, classical cytogenetics has been less successful because of the complexity of karyotypes or difficulty of culturing tumor cells in vitro. Chromosomal comparative ...

A collaborative study emanating from the Sanger Institute, for example, explored global variation in copy number in the human genome using both array-based CGH and SNP genotyping, describing it as ...