In conclusion, our studies show that CD44 has a key role in homing and engraftment of BCR-ABL–expressing leukemia-initiating cells in the mouse. We consider CD44 a promising target for preventing ...

The molecule called CD44 is a transmembrane glycoprotein involved in cell to cell adhesion, interactions, and signaling. It is also a receptor of hyaluronic acid (HA) which is mechanistically involved ...

One of the main obstacles to successfully treating breast cancer is the cells' ability to change in ways that make them resistant to treatment. Understanding the cellular mechanisms that mediate this ...

Protein biosignature identified by LC-MS/MS in classifying breast cancer and predicting tumor response to neoadjuvant therapy. Methods: Histological analysis of the breast was carried out on mounted ...

Due to their rapid metastatic spread, pancreatic tumors are among the most aggressive types of cancer. Only three to five percent of patients have a survival rate of five years. A team of researchers ...

Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia. Adjuvant cyclophosphamide, methotrexate, and fluorouracil versus fluorouracil, ...

Researchers investigating the role of the protein CD44 in obesity and metabolic health found that CD44-deficient mice stayed lean even on a high-fat diet, while the control mice developed obesity. A ...

A research team affiliated with UNIST has made a significant discovery explaining why liver cancers associated with obesity ...

Studies in mice and humans show fibroblasts that overexpress HAS2 develop an aggressive phenotype. Scientists have implicated an interplay between overexpression of hyaluronan synthase 2 (HAS2) and ...

Abstract Endotrophin (ETP) is a cleavage fragment of collagen VI α3 (COL6A3) that functions as a potent fibrotic and pro-tumorigenic factor. ETP is a ...

A group of researchers from the University of Seville and the Seville Biomedicine Institute (Instituto de Biomedicina de Sevilla - IBiS) has published a study in which they determine that a protein ...