A cellular recycling system called CMA was found to be impaired in ALS motor neurons. Reduced CMA activity was linked to TDP-43 protein clumps, a hallmark of most ALS cases. Boosting CMA may be a ...
Regulated changes in protein conformation can have profound effects on protein function, although routine laboratory methods often fail to detect them. The recently discovered BAG-family proteins may ...
Heat shock protein 90 (Hsp90) is an essential eukaryotic molecular chaperone. To properly chaperone its clientele, Hsp90 proceeds through an ATP-dependent conformational cycle influenced by ...
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