Nature

Deletion and Insertion Mutations in Short Tandem Repeats in the Coding Regions of Human Genes

In vitro studies in bacterial, yeast and eukaryotic systems have demonstrated the existence of deletion and insertion ‘hotspots’ involving repetitive sequences. Slipped-strand mispairing (SSM) has ...
Nature

Extreme androgen resistance in a kindred with a novel insertion/deletion mutation in exon 5 of the androgen receptor gene

Androgen insensitivy syndrome (AIS) is the most frequent cause of male pseudohermaphroditism resulting from target-organ resistance to androgen action. Individuals bearing the complete form of the ...
The American Journal of Managed Care

City of Hope’s Afkhami Discusses NSCLC With EGFR Exon 20 Insertion-Positive Mutations

Michelle Afkhami, MD, of City of Hope, joins The American Journal of Managed Care® (AJMC®) for a discussion on EGFR exon 20 insertion positive mutations in non-small cell lung cancer. Michelle Afkhami ...