Multiple sclerosis (MS) is a debilitating neurological disorder caused by malfunctioning immune responses that target the ...

How does the gut cause Multiple Sclerosis? New research identifies the MHC II protein in intestinal epithelial cells as the trigger for MS-related neuroinflammation. Discover how gut-primed T cells ...

Researchers reveal that CD4+ T cells can kill cancer cells lacking MHC I by triggering ferroptosis, challenging established ...

Researchers suggest modulating intestinal microbiota or antigen-presenting activity of IECs represents new approaches to treating autoimmune neurological disease.

Major histocompatibility complex class II (MHC-II) molecules play a critical, yet historically overlooked, role in tumor immunity. This review synthesizes emerging mechanistic evidence showing that ...

The major histocompatibility complex (MHC) region plays a crucial role in immune function; therefore, any genetic or epigenetic polymorphisms within the MHC locus may result in various diseases, as ...

MHC class II molecules are central to the adaptive immune response, serving as the means by which antigen-presenting cells, notably dendritic cells, display processed peptides to CD4+ T cells. This ...

T cells are pivotal mediators of the adaptive immune response, with cytotoxic CD8+ T lymphocytes recognising peptides displayed by MHC class I molecules. This antigen presentation process involves the ...

In a paradigm breaking study, Dr. Pavan Reddy, director of the Dan L Duncan Comprehensive Cancer Center at Baylor College of Medicine (BCM) and his team, in collaboration with Drs. Arul Chinnaiyan, S ...

Adaptative immune response mediated by NKG2D receptor and its ligand NKG2DL could be the clue for CD8-expressing “killer” T cells to kill tumors lacking the major histocompatibility complex (MHC) ...