In a prospective study of patients with stages I-III Merkel cell carcinoma (MCC), seropositivity for rising polyomavirus oncoprotein antibody titers conferred a 58% risk for recurrence at 12 months, ...

Cancer is a famously complex disease. Despite sharing the ‘cancer’ label, different cancer types can be as structurally and functionally diverse as the tissues from which they arise—physicians and ...

Scientists behind a new type of immunotherapy are demonstrating significant effects in laboratory experiments in cell samples from patients with the aggressive form of skin cancer, Merkel cell ...

ctDNA testing effectively stratifies Merkel cell carcinoma patients into high and low recurrence risk categories, influencing surveillance strategies. The study's cohorts revealed significant ...

BIRMINGHAM, Ala. – Transduction is the changing of one form of energy into another, such as a spoken voice changed into radio waves by a cellphone. Ten years ago, three research teams published a ...

Merkel cell polyomavirus is one of seven viruses known to cause cancer in humans. Infection with this virus is asymptomatic, but, rarely, it can lead to the development of Merkel cell carcinoma (MCC), ...

Tumor-wide RNA splicing aberrations and their potential as therapeutic neoantigen targets. Phase 1/2, open-label, first-in-human study of the anti-GPC3 T-cell engager SAR444200 in patients with ...

Merkel cell carcinoma (MCC) is an aggressive skin cancer with a 40% recurrence rate, lacking effective prognostic biomarkers and surveillance methods. This prospective, multicenter, observational ...

Incidence is increasing faster than melanoma, with typical presentation in the mid-70s and risk amplified by UV exposure, fair skin, immunosuppression, and MCPyV-associated oncogenesis. Accurate ...