Over the past two decades, researchers have learned that DNA inside the cell nucleus naturally folds into a network of ...

As we age, our cells don’t just wear down—they reorganize. Researchers found that cells actively remodel a key structure called the endoplasmic reticulum, reducing protein-producing regions while ...

Researchers at the Icahn School of Medicine at Mount Sinai have characterized how cellular senescence—a biological process in which aging cells change how they function—is associated with human brain ...

Advancements in spatial proteomics enable detailed tissue mapping, linking protein localization to disease mechanisms and ...

In A Nutshell As cells age, they deliberately shrink a major internal structure called the endoplasmic reticulum. This downsizing happens early in adulthood and shifts cells away from protein ...

Spatial proteomics enables scientists to investigate protein organization at the subcellular, cellular, and tissue levels, including in pathological contexts. Using technologies that help researchers ...

Findings from the Living Brain Project reveal how senescence processes involved in early brain development may also shape brain aging ...

In a recent study published in the journal Nature, a large team of researchers from the United States (U.S.) used single-cell ribonucleic acid (RNA) sequencing combined with high-resolution ...

One of the most fundamental processes in all of biology is the spontaneous organization of cells into clusters that divide and eventually turn into shapes – be they organs, wings, or limbs. Scientists ...