Protein-Protein Interactions (PPIs) are critical for biological systems to function properly. Strong interactions maintain structural integrity and function, whereas weaker interactions enable ...

Until recently, protein–protein interactions (PPIs) were seen to present contact surfaces too broad and featureless to give newly developed PPI-modulating drugs much purchase. Developers of such drugs ...

Scientists have designed a publicly-available software and web database to break down barriers to identifying key protein-protein interactions to treat with medication. The computational tool is ...

Researchers use machine learning to assign ‘fingerprints’ to proteins based on their surface affinity alone, predicting which proteins would interact based on these molecular fingerprints. A study led ...

Learn how experts in various techniques, such as surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC), measure protein–protein interactions (PPIs) for therapeutic development.

Proteins function through interactions with other proteins or peptides, a complex process that is still not fully understood. Current research focuses on how amino acid residues interact in ...

The pros and cons of moonlighting—taking up an extra job in addition to full-time employment—are hotly debated. But in biology, moonlighting is not uncommon, as individual proteins often perform ...

Cells constantly monitor and recycle their proteins through a tightly regulated waste-disposal system. Proteins that are no ...

Results of thioflavin T fluorescence analyses revealed a drastic increase in the fluorescence intensity when BSA was mixed with ultra-small (10 nm) silica nanoparticles (NPs) with a stirring time of ...

Expression proteomics determines where and when proteins are expressed and measures their quantities. This qualitative and quantitative approach can compare protein expression across conditions, such ...